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KMID : 0388120060150010018
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Journal of Korean Society for the Study of Obesity
2006 Volume.15 No. 1 p.18 ~ p.25
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Homocystein and Interleukin-6 Polymorphism in Obesity of Korean Adults
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Kim Kyung-A
Kang Jae-Heon
Song Hong-Ji
Jo Eun-Jin
Han Jung-Soon
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Abstract
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Background: The purpose of this study was to investigate the association of homocystein and Interleukin-6 (IL-6) with obesity in Korean subjects and the prevalence of the polymorphism of IL-6 gene among Koreans.
Method: Subjects were recruited from a health promotion center in a university hospital in Seoul. Subjects’ anthropometric measurements, blood pressure, homocysteine level, plasma lipid profile and fasting glucose were assessed. The prevalence of IL-6 polymorphism and its association with obesity were studied.
Result: Total 269 Korean individuals, including 116 (43.1%: Age 39.40 ± 8.48yr; BMI 20.71 ± 1.59 kg/m2) normal weight subjects and 153 (56.9%: Age 41.16 ±8.34yr; BMI 25.52 ± 1.90 kg/m2) overweight and obese subjects were studied. Subjects in the obese group had higher level of homocysteine than that in the normal weight group, 13.02 ± 4.74 umol/L vs. 11.00 ± 4.21 umol/L respectively ( P< 0.001) but the difference was disappeared in analysis after stratification according tosex. Out of the total 269 subjects, there were 268 individuals with GG phenotype (99.6%), only one overweight female with GC phenotype (0.4%) and no one with the CC phenotype (0%). The association of IL-6 polymorphism and obesity was not observed in Koreans.
Conclusion: We couldn’t find the association of homocystein and obesity in Korean. IL-6 polymorphism was very low in Koreans comparing to Caucasian and there was no relationship IL-6 polymorphism and obesity in Korean.
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KEYWORD
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IL-6, SNP, Obesity, homocysteine
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